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Ivermectin. Residue Monograph prepared by the meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), 81st meeting 2015

JECFA Monographs 18

Year of publication 2016

Pages 37 p.

Publisher FAO/WHO ;

Product type Document

Category Other document

Series title Joint FAO/WHO Expert Committee on Food Additives (JECFA) Monographs

Edition 1

Synopsis (short abstract) Ivermectin (CAS No. 70288-86-7)2 is a macrocyclic lactone that is a member of the avermectin series and is widely used as a broad-spectrum antiparasitic endectocide against nematode and arthropod parasites in food-producing animals. In human medicine, ivermectin is used to treat onchocerciasis, lymphatic filariasis, strongiloidiasis and scabies. Ivermectin consists of two homologous compounds, 22,23-dihydroavermectin B1a (H2B1a or ivermectin B1a) and 22,23-dihydroavermectin B1b (H2B1b or ivermec tin B1b), in the H2B1a:H2B1b ratio of 80:20. Ivermectin is used in cattle, sheep, goats, pigs, horses, reindeer and American bison at doses of 0.1–0.5 mg/kg bw given subcutaneously, topically or orally, as a single dose treatment only. Withdrawal periods range from 14 to 122 days where ivermectin is approved for use.

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