This report aims at inspiring strategic thinking and actions to transform agrifood systems towards a sustainable, resilient and inclusive future. It builds on both previous reports in the same series as well as on a comprehensive corporate strategic foresight exercise that also nurtured the FAO Strategic Framework 2022–31. The report analyses major drivers of agrifood systems and explores how their trends could determine alternative futures of agrifood, socioeconomic and environmental systems. The fundamental message of this report is that it is still possible to push agrifood systems along a pattern of sustainability and resilience, if key “triggers” of transformation are properly activated. However, strategic policy options to activate them will have to “outsmart” vested interests, hidden agendas and conflicting objectives, and trade-off short-term unsustainable achievements for longer-term sustainability, resilience and inclusivity.