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Residue evaluation of certain veterinary drugs

Joint FAO/WHO Expert Committee on Food Additives, 94th Meeting (Virtual) 16–27 May 2022













FAO & WHO. 2023. Residue evaluation of certain veterinary drugs – Joint FAO/WHO Expert Committee on Food Additives, 94th Meeting (Virtual) 16–27 May 2022. Joint FAO/WHO Expert Committee on Food Additives (JECFA) Monographs, No. 28. Rome.




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    Residue evaluation of certain veterinary drugs
    Joint FAO/WHO Expert Committee on Food Additives, 98th Meeting 20–29 February 2024
    2024
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    This volume of FAO JECFA Monographs contains residue evaluation of certain veterinary drugs prepared at the 98th Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), held from 20 to 29 February 2024. This JECFA meeting was convened specifically to consider residues of veterinary drugs in food-producing animal species. The tasks for the Committee were to further elaborate principles for evaluating the safety of residues of veterinary drugs in food and for establishing acceptable daily intakes (ADIs) and/or acute reference doses (ARfDs), and to recommend maximum residue limits (MRLs) for substances when they are administered to food-producing animals in accordance with good veterinary practice (GVP) in the use of veterinary drugs. The present volume contains monographs on the evaluations of residue data of substances scheduled for evaluation at the request of the Codex Committee on Residues of Veterinary Drugs in Food. A summary of the recommendations on compounds is also presented in this report. The enclosed monographs provided the scientific basis for the recommendations of MRLs.
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    Residue evaluation of certain veterinary drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA). 66th meeting 2006 2006
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    The monographs in this volume of the FAO JECFA Monographs on the residues of, statements on, or other parameters of the veterinary drugs on the agenda were prepared by the invited experts for the sixty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) held in Rome, Italy, 22-28 February, 2006. This was the seventeenth meeting of JECFA convened specifically to consider residues of veterinary drugs in food animals. The Committee has evaluated residues of veterinary drug s in food animals at the 12th, 26th, 27th, 32nd, 34th, 36th, 38th, 40th, 42nd, 43rd, 45th, 47th, 48th, 50th, 52nd, 54th, 58th, 60th, and 62nd meetings (Ref. 1-15 and 19-22, respectively). The tasks for the Committee were to further elaborate principles for evaluating the safety of residues of veterinary drugs in food and for establishing acceptable daily intakes (ADIs) and recommend maximum residue limits (MRLs) for substances on the agenda when they are administered to food producing animals in accordance with good veterinary practice in the use of veterinary drugs. The enclosed monographs provided the scientific basis for the recommendations of MRLs. There are two significant items in this volume of the FAO JECFA Monographs to bring to the attention of readers. First, this volume is the first in a new format for the presentation of monographs from meetings of the Committee. Second, this was the first meeting of JECFA subsequent to the completion of the workshop to update the principl es and methods of risk assessment for MRLs for pesticides and veterinary drugs, held jointly by FAO/RIVM/WHO, in Bilthoven, The Netherlands, 7 - 11 November, 2005. Specifically, the Committee decided to implement one of the more significant recommendations in the workshop report – the concept of using median residue values to estimate daily intakes of residues of veterinary drugs in food for chronic exposure intake estimates (Ref. 24).
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    Residue Evaluation of Certain Veterinary Drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA). 70th meeting, 2008. FAO JECFA Monographs 6 2009
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    This document contains monographs on residue evaluations of certain veterinary drugs, prepared at the seventieh meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which was held in Geneva, Switzerland from 21 to 29 October 2008. Three substances were evaluated for the first time for the animal species concerned, avilamycin, monensin and narasin. Four substances were reassessed, dexamethasone, tilmicosin, triclabendazole and tylosin. The residue monographs provide informatio n on chemical identity and properties of the compounds, pharmacokinetics and metabolism, residue depletion studies and analytical methods validated and used for the detection and quantification of the compounds. In addition to these monographs, this document includes the considerations and recommendations developed by the Committee for residues of veterinary drugs in honey and possible approaches to derive MRLs for this commodity; and a monograph on residues in aquatic species of and an estimata tion of human dietary exposure to malachite green (an antimicrobial agent and contamimant). This publication and other documents produced by JECFA contain information that is useful to those who work with or are involved with recommending or controlling maximum residue limits for veterinary drugs in foods.

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