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Book (series)Drug management and parasite resistance in bovine trypanosomiasis in Africa 1998
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No results found.Trypanocidal drugs remain the principal method of animal trypanosomiasis control in most African countries. However, there is growing concern that their future effectiveness may be severely curtailed by widespread drug resistance. This document presents an overview of the current situation of resistance to drugs for the chemotherapy of trypanosomiasis in African livestock. Although the number of case reports on drug resistance is increasing, there is a lack of reliable data at the regional or national level on the true prevalence and impact of drug resistance. In order to compare data on a temporal and spatial basis across Africa there is an urgent need for better standardization of tests for the detection of drug resistance. The advantages and disadvantages of the currently available assays are briefly reviewed and measures suggested to improve the situation. Finally, some guidelines on delaying the development of drug resistance are proposed and measures which may be adopted to control drug resistance when it occurs are recommended. Although there is still a lack of knowledge about the mechanisms of resistance and the factors responsible for the development of drug resistance, urgent measures are needed to maintain the efficacy of the existing drugs. Based on experiences of the control of resistance to other drugs such as antimalarials, antibiotics and anthelmintics it is suggested that reliance on the "sanative pair" guideline might not be sufficient to control resistance to trypanocides. This guideline needs to be accompanied by the following additional measures: -
Brochure, flyer, fact-sheet10 Raisons de ne pas conserver le virus de la peste bovine en laboratoire 2015Rinderpest, or ‘’cattle plague’’, was an acute, highly contagious disease affecting several species of wild and domestic cloven-hoofed animals, notably cattle and buffalo. It killed millions of cattle over the millennia in Africa, Asia and Europe and was officially declared eradicated in 2011 at conferences of The World Organisation for Animal Health (OIE) and of the Food and Agriculture Organization of the United Nations (FAO). At these historical celebrations the Member States of each organiza tion recommended that countries should destroy their rinderpest virus stocks or send them to a FAO-OIE approved Rinderpest Holding Facility to ensure freedom from the disease.
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