24. TMDI calculations, based on the approach described in the “Guidelines for Predicting Dietary Intake of Pesticide Residues”[11] as modified by the York Consultation, were carried out on pesticides considered by the 1995 JMPR, except for those pesticides for which no MRLs had been proposed or where all existing MRLs/CXLs had been proposed for withdrawal.
25. In calculations for the Committee, the retention of general CXLs for commodity groups that were otherwise recommended for withdrawal by the JMPR, resulted in estimates of exposure for certain pesticides, e.g., dicofol, that were much greater than their corresponding ADIs and would prevent the advancement of MRLs for individual commodities beyond Step 7C under current procedure. Consequently, the Committee agreed that calculations of estimated exposure should not include such group commodities.
26. Of the 24 pesticides considered, 22 compounds had TMDIs none of which exceeded the ADI for all regional/cultural diets. These are: abamectin, azinphos-methyl, buprofezin, captan, carbendazim, chlorpyrifos, dithianon, dithiocarbamates, ethephon, fenarimol, fenpropimorph, fenthion, flusilazole, folpet, iprodione, metalaxyl, parathion, penconazole, piperonyl butoxide, profenofos, thiophanate-methyl and triadimefon.
27. For two compounds, parathion-methyl and vinclozolin, the TMDI exceeded the ADI in one or more of the 5 regional/cultural diets. International Estimated Dietary Intakes (IEDIs) were calculated for parathion-methyl based on available processing studies. While substantially lower than the TMDIs, the IEDIs were still above the ADIs for some of the regional/cultural diets. However, the use of Supervised Trials Median Residue (STMR) was expected to significantly improve the estimate of likely exposure.
