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ArticleImmunogenicity of Oral Rabies Vaccine Strain SPBN GASGAS in Local Dogs in Bali, Indonesia 2023
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No results found.Dog-mediated rabies is endemic in much of Indonesia, including Bali. Most dogs in Bali are free-roaming and often inaccessible for parenteral vaccination without special effort. Oral rabies vaccination (ORV) is considered a promising alternative to increase vaccination coverage in these dogs. This study assessed immunogenicity in local dogs in Bali after oral administration of the highly attenuated third-generation rabies virus vaccine strain SPBN GASGAS. Dogs received the oral rabies vaccine either directly or by being offered an egg-flavored bait that contained a vaccine-loaded sachet. The humoral immune response was then compared with two further groups of dogs: a group that received a parenteral inactivated rabies vaccine and an unvaccinated control group. The animals were bled prior to vaccination and between 27 and 32 days after vaccination. The blood samples were tested for the presence of virus-binding antibodies using ELISA. The seroconversion rate in the three groups of vaccinated dogs did not differ significantly: bait: 88.9%; direct-oral: 94.1%; parenteral: 90.9%; control: 0%. There was no significant quantitative difference in the level of antibodies between orally and parenterally vaccinated dogs. This study confirms that SPBN GASGAS is capable of inducing an adequate immune response comparable to a parenteral vaccine under field conditions in Indonesia. -
DocumentStrengthening Rabies Eradication in Bali, Indonesia - TCP INS 3504 2018
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No results found.Rabies poses a serious threat to animal and human health and people’s livelihoods in many parts of Asia. Following a serious rabies outbreak in 2010, the Government of Indonesia began a widespread campaign to control the spread of the virus in Bali. In 2014, human and animal rabies cases began to rapidly increase again and this project aimed to support government efforts for mass dog vaccinations and to pilot a comprehensive dog population management strategy. The objective was to develop the technical capacity for effective rabies control and to help bring the rabies eradication campaign back on track. -
Brochure, flyer, fact-sheetA neglected zoonotic disease: Dog-Mediated Rabies, Eliminating Human Deaths from by 2030 2018
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No results found.Rabies is a preventable and fatal viral disease that kills an estimated 59 000 people every year. The virus is transmitted to people and other animals from exposure to the saliva of infected animals through bites and scratches. Most deaths occur in children in poor and rural communities living in Asia and Africa, where awareness about the disease and access to human and dog vaccines is limited. As a result, dog-mediated rabies is still present in over 150 countries, and its true burden is much higher than what is reported as many cases are not recognized or recorded. This underreporting of rabies cases in animals and humans remains the main reason for the lack of reliable data on the number of rabies cases and their impact on communities and society as a whole.
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