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Immunogenicity of Oral Rabies Vaccine Strain SPBN GASGAS in Local Dogs in Bali, Indonesia

Year of publication 2023

Place of publication Jakarta, Indonesia ;

Pages 11p.

Author Megawati Saputra, I.L., Suwarno, S., Husein, W.F., Suseno, P.P., Prayoga, I.M.A. et al. ;

Publisher FAO ;

Product type Article

Synopsis (short abstract) Dog-mediated rabies is endemic in much of Indonesia, including Bali. Most dogs in Bali are free-roaming and often inaccessible for parenteral vaccination without special effort. Oral rabies vaccination (ORV) is considered a promising alternative to increase vaccination coverage in these dogs. This study assessed immunogenicity in local dogs in Bali after oral administration of the highly attenuated third-generation rabies virus vaccine strain SPBN GASGAS. Dogs received the oral rabies vaccine either directly or by being offered an egg-flavored bait that contained a vaccine-loaded sachet. The humoral immune response was then compared with two further groups of dogs: a group that received a parenteral inactivated rabies vaccine and an unvaccinated control group. The animals were bled prior to vaccination and between 27 and 32 days after vaccination. The blood samples were tested for the presence of virus-binding antibodies using ELISA. The seroconversion rate in the three groups of vaccinated dogs did not differ significantly: bait: 88.9%; direct-oral: 94.1%; parenteral: 90.9%; control: 0%. There was no significant quantitative difference in the level of antibodies between orally and parenterally vaccinated dogs. This study confirms that SPBN GASGAS is capable of inducing an adequate immune response comparable to a parenteral vaccine under field conditions in Indonesia.

Open access article. This article is academically peer reviewed and published externally.” This article is published in Viruses15, no. 6: 1405, 20 June 2023

Cite this content as:

Megawati Saputra, I.L.; Suwarno, S.; Husein, W.F.; Suseno, P.P.; Prayoga, I.M.A.; Vos, A.; Arthawan, I.M.; Schoonman, L.; Weaver, J.; Zainuddin, N. Immunogenicity of Oral Rabies Vaccine Strain SPBN GASGAS in Local Dogs in Bali, Indonesia. Viruses 2023, 15, 1405. https://doi.org/ 10.3390/v15061405

Language English

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