Presentation of PPR-Rabies vaccination

Mohamed Alpha Bah

Presentation of PPR-Rabies vaccination

Panel discussion on joint vaccination focused on Rabies and PPR

Year of publication 2022

Place of publication Rome, Italy ;

Pages 21

Author Mohamed Alpha Bah

Publisher Government of Sierra Leone, Ministry of Agriculture and Forestry ;

Product type Presentation

Edition 1

Full item page

Language English

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Book (stand-alone)

Oral vaccination of dogs against rabies
Recommendations for field application and integration into dog rabies control programmes
2023

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This technical report replaces or supersedes issue-related contents in previous WHO foundational documents on oral rabies vaccination (ORV) of dogs. In contrast to the 2007 WHO recommendations, this report will shift focus from the development of suitable vaccines and baits for dogs towards providing guidance for practical implementation of ORV as a tool integrated into national strategies to control rabies in dog populations. This report therefore mainly addresses basic regulatory considerations for licensing and selection of appropriate oral vaccine candidates, logistics, distribution strategies in the field, communication, activities to be implemented in relation to ORV campaigns, and monitoring of campaigns. It should be emphasized that it is impossible to establish a universally valid and applicable blueprint for the integration of ORV into national strategies for the control of canine rabies. This is not least due to country-specific circumstances, including sociocultural aspects, epidemiological situations, local dog population structures, funding, and available resources. Therefore, countries should use this guiding document to find their own strategic and practical approach.
Presentation

Integrating Dog Rabies Vaccination Strategies
Panel discussion on joint vaccination focused on Rabies and PPR
2022

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Article

Immunogenicity of Oral Rabies Vaccine Strain SPBN GASGAS in Local Dogs in Bali, Indonesia 2023

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Dog-mediated rabies is endemic in much of Indonesia, including Bali. Most dogs in Bali are free-roaming and often inaccessible for parenteral vaccination without special effort. Oral rabies vaccination (ORV) is considered a promising alternative to increase vaccination coverage in these dogs. This study assessed immunogenicity in local dogs in Bali after oral administration of the highly attenuated third-generation rabies virus vaccine strain SPBN GASGAS. Dogs received the oral rabies vaccine either directly or by being offered an egg-flavored bait that contained a vaccine-loaded sachet. The humoral immune response was then compared with two further groups of dogs: a group that received a parenteral inactivated rabies vaccine and an unvaccinated control group. The animals were bled prior to vaccination and between 27 and 32 days after vaccination. The blood samples were tested for the presence of virus-binding antibodies using ELISA. The seroconversion rate in the three groups of vaccinated dogs did not differ significantly: bait: 88.9%; direct-oral: 94.1%; parenteral: 90.9%; control: 0%. There was no significant quantitative difference in the level of antibodies between orally and parenterally vaccinated dogs. This study confirms that SPBN GASGAS is capable of inducing an adequate immune response comparable to a parenteral vaccine under field conditions in Indonesia.