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Updated joint FAO/WHO/WOAH assessment of recent influenza A(H5N1) virus events in animals and people

14 August 2024









FAO, WHO, WOAH. 2024. Updated joint FAO/WHO/WOAH assessment of recent influenza A(H5N1) virus events in animals and people – 18 July 2024. Rome, Geneva, Paris. 


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    During 2020, highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b viruses arose from previously circulating influenza A(H5Nx) viruses and spread predominantly via migratory birds to many parts of Africa, Asia and Europe. The epizootic has led to unprecedented numbers of deaths in wild birds and caused outbreaks in domestic poultry. In late 2021, these viruses crossed to North America and subsequently South America in October 2022. Additionally, globally, there have been increased detections of A(H5N1) viruses in non-avian species including wild and domestic (including companion and farmed) terrestrial and marine mammals and, more recently in goats and dairy cattle in the United States of America. The majority, with some regional exceptions, of the HPAI A(H5N1) viruses characterized genetically since 2020 belong to the 2.3.4.4b clade. Since the beginning of 2021, 28 detections of A(H5N1) in humans have been reported to WHO, including a case who had exposure to dairy cattle presumed to be infected with A(H5N1) virus. Of these human cases, where the haemagglutinin (HA) H5 clade is known, 13 have been caused by clade 2.3.4.4b viruses. This joint FAO/WHO/WOAH risk assessment focuses on A(H5N1) viruses characterized since 2021 and assesses the public health risk as well as the risk of the virus spread among animals.
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    The history of the battle to control HPAI in Viet Nam is relatively short but within the past 10 years there have been many insights developed, as well as some twists and turns in the road to the current level of success. As the concerted HPAI effort supported by FAO is coming to an end, albeit to be adapted into a broader One Health approach to animal health and zoonotic diseases, it was considered timely that a retrospective overview of the programme be produced to capture key elements and lessons that have arisen. A key adjunct for this retrospective is the FAO document ‘Lessons from HPAI – a technical stocktaking of outputs, outcomes, best practices and lessons learned from the fight against highly pathogenic avian influenza in Asia 2005-2011’. Consistent with that stocktake, this retrospective on the HPAI control effort in Viet Nam does not attempt to be a comprehensive compilation of all the outputs and outcomes from the HPAI programme, but is rather a synopsis that captures the key experiences and challenges faced in Viet Nam in addressing this complex disease problem, concentrating on the USAID inputs but also with reference to other project areas as appropriate. This document examines the HPAI situation in Viet Nam at several points during the last 8 years through the prism of activities and outcomes in key areas such as coordination, surveillance, laboratory services, vaccination, biosecurity, socio-economics and communications and advocacy.
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    Vaccination can play a valuable role in control, prevention and elimination of highly pathogenicity avian influenza (HPAI) viruses in poultry. However, risk of adverse consequences as well as concerns about availability of sufficient resources to conduct vaccination programmes often restrain countries from embarking on vaccination. This document discusses concerns regarding poultry vaccination for H5 HPAI, with the aim to facilitate decision making in affected countries or those at risk of H5 HP AI incursion. The document contributes to FAO’s Strategic Objective 5 by helping to increase the resilience of livelihoods to threats from HPAI.

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