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MeetingSteviol Glycosides, 82nd JECFA—Chemical and Technical Assessment (CTA), 2016 2016
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No results found.Steviol glycosides are a group of compounds naturally occurring in the plant Stevia rebaudiana Bertoni sharing a similar molecular structure where different sugar moieties are attached to the aglycone steviol (an ent-kaurene-type diterpene). They include any compound containing a steviol backbone conjugated to any number or combination of the principal sugar moieties in any of the orientations occurring in the leaves of Stevia rebaudiana Bertoni including, glucose, rhamnose, xylose, fructose, an d deoxyglucose. Newly revised specification for Steviol Glycosides are divided into two monographs by source. -
Document(Framework for) Steviol Glycosides 2021
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No results found.Steviol glycosides produced by extraction from the leaves of Stevia rebaudiana Bertoni were reviewed by the Committee at its fifty-first, sixty-third, sixty-eighth, eighty-second, eighty-fourth, eighty-seventh and ninety-first meetings. At the sixty-eighth meeting the Committee extended the previously designated temporary ADI of 0–2 mg/kg bw for steviol glycosides, expressed as steviol, pending submission of the results of then-ongoing studies by the end of 2008. The sixty-eighth meeting also removed the ‘tentative’ designation on the specifications for steviol glycosides. At the sixty-ninth meeting, the Committee received additional data and reevaluated steviol glycosides from S. rebaudiana Bertoni. The Committee at that meeting concluded that the data was sufficient to establish an ADI for steviol glycosides of 0–4 mg/kg bw, expressed as steviol equivalents. A specifications monograph for Steviol glycosides was prepared, which needs to be uploaded on teh FAO JECFA Food additives database. -
MeetingRebaudioside a From Multiple Gene Donors Expressed in Yarrowia Lipolytica
Residue Monograph prepared by the meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), 82nd meeting 2016
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No results found.Prepared at the 82nd JECFA (2016) and published in FAO JECFA Monograph 19 (2016), superseding specifications for Oxidized starch included in the specifications for Modified starches prepared at the 79th JECFA (2014), published in FAO JECFA Monographs 16 (2014). An ADI “not specified” was established at the 26th JECFA (1982). Rebaudioside A is a steviol glycoside composed predominantly of rebaudioside A with minor amounts of other steviol glycosides such as rebaudioside B, rebaudioside D, rebaudi oside M, and stevioside. Rebaudioside A is obtained from the fermentation of a non-toxigenic non-pathogenic strain of Yarrowia lipolytica that is genetically modified with heterologous genes from multiple donor organisms to overexpress steviol glycosides. After removal of the biomass by solid-liquid separation and heat treatment, the process involves concentration of the steviol glycosides (e.g. by resin adsorption), followed by purification of the rebaudioside A by crystallization and drying. I on exchange resins may be used in the purification process. The final product may be spray-dried.
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