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Evaluation of certain veterinary drug residues in food: Ninety-eighth report of the Joint FAO/WHO Expert Committee on Food Additives

WHO Technical Report Series, No. 1055.











WHO & FAO. 2024. Evaluation of certain veterinary drug residues in food: ninety-eighth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, No. 1055. Geneva.





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    Toxicological evaluation of certain veterinary drug residues in food: prepared by the ninety-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA)
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    The monographs contained in this volume were prepared at the ninety-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which met at the headquarters of the Food and Agriculture Organization of the United Nations (FAO) in Rome, Italy, on 20–29 February 2024. The toxicological monographs in this volume summarize data on the veterinary drug residues that were evaluated toxicologically by the Committee: clopidol, fumagillin dicyclohexylmine, and imidacloprid. Annexed to the report is a summary of the Committee’s recommendations on these drugs, including acceptable daily intakes (ADIs), acute reference doses (ARfDs) and proposed maximum residue limits (MRLs). This volume and others in the WHO Food Additives Series contain information that is useful to those who produce and use food additives and veterinary drugs and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories and universities.
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    Toxicological evaluation of certain veterinary drug residues in food: prepared by the ninety-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) 2023
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    This volume contains monographs prepared at the ninety-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which met in a virtual format, from 16 to 27 May 2022. The toxicological monographs in this volume summarize data on the veterinary drug residues that were evaluated toxicologically by the Committee: imidacloprid and nicarbazin. Annexed to the report is a summary of the Committee’s recommendations on these and other drugs (ivermectin and selamectin) discussed at the ninety-fourth meeting, including acceptable daily intakes (ADIs), acute reference doses (ARfDs) and proposed maximum residue limits (MRLs). This volume and others in the WHO Food Additives Series contain information that is useful to those who produce and use food additives and veterinary drugs, and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories and universities.
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    Evaluation of certain veterinary drug residues in food: ninety-fourth report of the Joint FAO/WHO Expert Committee on Food Additives
    WHO Technical Report Series, no. 1041
    2022
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    This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of residues of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). It covers topics such as the parallel review process; estimation of dietary exposure to veterinary drug residues; a risk-based decision tree approach for safety evaluation; assessment of the potential effects of residues on the human intestinal microbiome. Summaries follow the Committee’s evaluations of toxicological and residue data on a variety of veterinary drugs: two antiparasitic agents (imidacloprid, ivermectin) and one coccidiostat (nicarbazin). Additionally, further evaluation of the parasiticide selamectin is included as part of a pilot in support of the proposed parallel review process. Annexed to the report is a summary of the Committee’s recommendations on these drugs, including acceptable daily intakes and proposed maximum residue limits.

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