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Strengthening Capacity towards Rabies Elimination in Asia - TCP/RAS/3708








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    Brochure, flyer, fact-sheet
    A neglected zoonotic disease: Dog-Mediated Rabies, Eliminating Human Deaths from by 2030 2018
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    Rabies is a preventable and fatal viral disease that kills an estimated 59 000 people every year. The virus is transmitted to people and other animals from exposure to the saliva of infected animals through bites and scratches. Most deaths occur in children in poor and rural communities living in Asia and Africa, where awareness about the disease and access to human and dog vaccines is limited. As a result, dog-mediated rabies is still present in over 150 countries, and its true burden is much higher than what is reported as many cases are not recognized or recorded. This underreporting of rabies cases in animals and humans remains the main reason for the lack of reliable data on the number of rabies cases and their impact on communities and society as a whole.
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    Booklet
    United Against Rabies Forum – Zero by 30
    One Health in Action, December 2020
    2021
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    Rabies threatens nations worldwide, mainly affecting poor and marginalized communities in Africa and Asia. Its economic impact is estimated to be over USD 8.6 billion per year. If no new action is taken, a million people will die from rabies by 2030. FAO, OIE, and WHO have been committed to controlling and eliminating of human deaths from canine rabies since 2011, and in 2018 published “Zero by 30: The Global Strategic Plan to Eliminate Human Deaths from Dog-Mediated Rabies by 2030.” United Against Rabies (UAR) Forum is formed as a platform for stakeholders to work together and advance their collective efforts to achieve Zero by 30. The UAR Forum will bring organizations from all sectors including public and animal health specialists, One Health specialists, civil society, research and academic institutions, and the private sector as partners in this collaboration. FAO, OIE, and WHO leadership announced the UAR Forum at an online event in September 2020. The UAR Forum meeting included a wide range of stakeholders and speakers discussing the impact of rabies and its role as a model One Health challenge. The meeting included three technical expert panel sessions with contributions and questions from participants around the world. The ideas and suggestions raised through the discussions identified the priority action areas and activities to be addressed by UAR Forum working groups over the next 12 to 18 months in order to progress to the global goal of Zero by 30.
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    Article
    Immunogenicity of Oral Rabies Vaccine Strain SPBN GASGAS in Local Dogs in Bali, Indonesia 2023
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    Dog-mediated rabies is endemic in much of Indonesia, including Bali. Most dogs in Bali are free-roaming and often inaccessible for parenteral vaccination without special effort. Oral rabies vaccination (ORV) is considered a promising alternative to increase vaccination coverage in these dogs. This study assessed immunogenicity in local dogs in Bali after oral administration of the highly attenuated third-generation rabies virus vaccine strain SPBN GASGAS. Dogs received the oral rabies vaccine either directly or by being offered an egg-flavored bait that contained a vaccine-loaded sachet. The humoral immune response was then compared with two further groups of dogs: a group that received a parenteral inactivated rabies vaccine and an unvaccinated control group. The animals were bled prior to vaccination and between 27 and 32 days after vaccination. The blood samples were tested for the presence of virus-binding antibodies using ELISA. The seroconversion rate in the three groups of vaccinated dogs did not differ significantly: bait: 88.9%; direct-oral: 94.1%; parenteral: 90.9%; control: 0%. There was no significant quantitative difference in the level of antibodies between orally and parenterally vaccinated dogs. This study confirms that SPBN GASGAS is capable of inducing an adequate immune response comparable to a parenteral vaccine under field conditions in Indonesia.

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