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Implications of Maximum Residue Levels (MRLs) on tea trade









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    Book (series)
    Residue evaluation of certain veterinary drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA). 66th meeting 2006 2006
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    The monographs in this volume of the FAO JECFA Monographs on the residues of, statements on, or other parameters of the veterinary drugs on the agenda were prepared by the invited experts for the sixty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) held in Rome, Italy, 22-28 February, 2006. This was the seventeenth meeting of JECFA convened specifically to consider residues of veterinary drugs in food animals. The Committee has evaluated residues of veterinary drug s in food animals at the 12th, 26th, 27th, 32nd, 34th, 36th, 38th, 40th, 42nd, 43rd, 45th, 47th, 48th, 50th, 52nd, 54th, 58th, 60th, and 62nd meetings (Ref. 1-15 and 19-22, respectively). The tasks for the Committee were to further elaborate principles for evaluating the safety of residues of veterinary drugs in food and for establishing acceptable daily intakes (ADIs) and recommend maximum residue limits (MRLs) for substances on the agenda when they are administered to food producing animals in accordance with good veterinary practice in the use of veterinary drugs. The enclosed monographs provided the scientific basis for the recommendations of MRLs. There are two significant items in this volume of the FAO JECFA Monographs to bring to the attention of readers. First, this volume is the first in a new format for the presentation of monographs from meetings of the Committee. Second, this was the first meeting of JECFA subsequent to the completion of the workshop to update the principl es and methods of risk assessment for MRLs for pesticides and veterinary drugs, held jointly by FAO/RIVM/WHO, in Bilthoven, The Netherlands, 7 - 11 November, 2005. Specifically, the Committee decided to implement one of the more significant recommendations in the workshop report – the concept of using median residue values to estimate daily intakes of residues of veterinary drugs in food for chronic exposure intake estimates (Ref. 24).
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    Residue Evaluation of Certain Veterinary Drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA). 70th meeting, 2008. FAO JECFA Monographs 6 2009
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    This document contains monographs on residue evaluations of certain veterinary drugs, prepared at the seventieh meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which was held in Geneva, Switzerland from 21 to 29 October 2008. Three substances were evaluated for the first time for the animal species concerned, avilamycin, monensin and narasin. Four substances were reassessed, dexamethasone, tilmicosin, triclabendazole and tylosin. The residue monographs provide informatio n on chemical identity and properties of the compounds, pharmacokinetics and metabolism, residue depletion studies and analytical methods validated and used for the detection and quantification of the compounds. In addition to these monographs, this document includes the considerations and recommendations developed by the Committee for residues of veterinary drugs in honey and possible approaches to derive MRLs for this commodity; and a monograph on residues in aquatic species of and an estimata tion of human dietary exposure to malachite green (an antimicrobial agent and contamimant). This publication and other documents produced by JECFA contain information that is useful to those who work with or are involved with recommending or controlling maximum residue limits for veterinary drugs in foods.
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    Book (stand-alone)
    Evaluation of certain veterinary drug residues in food
    Eighty-eighth report of the Joint FAO/WHO Expert Committee on Food Additives
    2020
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    This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of residues of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), including harmonization of residue definition, use of scientific literature in risk assessment, toxicological profiling of compounds and less-than-lifetime dietary exposure assessment, combined exposure to multiple chemicals, and microbiological effects on the safety evaluation of veterinary drug residues in food. Summaries follow the Committee’s evaluations of toxicological and residue data on a variety of veterinary drugs: three insecticides (diflubenzuron, ethion and flumethrin), three antimicrobials (fosfomycin, halquinol and ivermectin) and one antiparasitic agent (selamectin). Annexed to the report is a summary of the Committee’s recommendations on these drugs, including acceptable daily intakes (ADIs) and proposed MRLs.

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