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Food Additives. FAO Guidelines on the Structure and Content of the Document called "Chemical and Technical Assessment (CTA)". Joint FAO/WHO Expert Committee on Food Additives (JECFA). Rome, February 2003







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    Polyvinyl Alcohol (PVA)-Polyethylene Glycol (PEG) Graft Co-Polymer - 80th Joint FAO/WHO Expert Committee on Food Additives (JECFA) Meeting - Chemical and Technical Assessment (CTA), 2015 2015
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    This Chemical and Technical Assessment summarizes data and information on polyvinyl alcohol (PVA)-polyethylene glycol (PEG) graft co-polymer (PVA-PEG graft co-polymer) as provided by the sponsor BASF in response to the call for data to the 80th Joint FAO/WHO Expert Committee Meeting on Food Additives (JECFA). PVA-PEG graft co-polymer is a synthetic branched co-polymer consisting of a main backbone of PEG and two to three side chains of PVA. The co-polymer is manufactured by grafting polyvinyl ac etate chains onto the PEG backbone which are then hydrolysed to form the PVA side chains. The final co-polymer consists of approximately 75% PVA units and 25% PEG units on a weight basis. PVA-PEG graft co-polymer is primarily intended for use as a film coating on food supplement products. Specifically, the sponsor is requesting that the co-polymer be considered for use as a glazing agent, binder for tablets and stabilizer in food supplements at a level not to exceed 10% in the food supplement. T he sponsor indicates that the final co-polymer formulation may contain 0.3 to 0.5% colloidal silica to improve the flow of the co-polymer in powder form.
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    Advantame - 80th Joint FAO/WHO Expert Committee on Food Additives (JECFA) Meeting - Chemical and Technical Assessment (CTA), 2015 2015
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    This Chemical and Technical Assessment document is based on data and information submitted by Ajinomoto Co., Inc., in the dossier dated December, 2012 and December 2014. Advantame was evaluated by JECFA at its 77th meeting. An ADI of 0-5 mg/kg body weight was established by the Committee and a toxicological monograph was prepared and published in WHO Food Additives Series: 68 (WHO, 2013). New tentative specifications were prepared at the 77th JECFA (2013) and published in FAO JECFA Monographs 14 (FAO, 2013) requesting information on: suitability of the head space GC method (using appropriate dissolution solvent) for determination of residual solvents, an alternative/improved HPLC method for the assay of advantame and acid of advantame using a standard curve, additional data and analytical methods for determination of palladium and platinum and information on the purity and availability of the commercial reference standards used in the assay of advantame and acid of advantame. Chemical and Technical Assessment document (CTA) was also prepared. At the 80th meeting, the Committee received and reviewed the requested data. Full specifications were prepared, and a Chemical and Technical Assessment was revised. Advantame (ANS9801 - laboratory code name) is an N-substituted (aspartic acid portion) derivative of aspartame that is used as a non-nutritive sweetener. INS No. 969 was assigned to advantame at the 45th Session of the CCFA in 2013 (FAO/WHO, 2013). Advantame has been demonstr ated to be approximately 100 times sweeter than aspartame and approximately 37000 times sweeter than sucrose. Advantame is manufactured via a chemical synthesis.
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    FAO Procedural Guidelines for the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Food Additives and Food Contaminants (Rome, February 2003) 2003
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    These notes are designed to provide guidance to the FAO Joint Secretary, FAO Consultants, Members and sponsors relating their roles and responsibilities in dealing with the evaluation of food additives and contaminants. The guidelines outline the tasks of the FAO Joint Secretariat and its role in servicing JECFA, time schedules to be followed in preparing for meetings, the appropriate handling of data, and appropriate relationships with sponsors and other data providers. Supplemental material is included that outlines the procedures by which substances may be placed on the agenda (Annex 1) and procedures for issuing the call for data (Annex 2). Close adherence to these guidelines by everyone involved will ensure that the concerns and views of all interested parties are taken into account in the decisions of JECFA and that the independence and integrity of the evaluations are maintained, both in appearance and in actual fact.

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