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Residues of some veterinary drugs in animals and foods. Joint FAO/WHO Expert Committee on Food Additives (JECFA), 62nd meeting 2004. FAO Food and Nutrition Paper 41/16











Contents

Joint FAO/WHO Expert Committee on Food Additives (JECFA) (62nd Meeting) Abbreviations Introduction References Cefuroxime sodium alpha-Cypermethrin and cypermethrin Doramectin Lincomycin Melengestrol acetate Pirlimycin Ractopamine hydrochloride Summary of JECFA evaluations of veterinary drug residues from the 32nd meeting to the present Summary of Recommendations from the 62nd JECFA on C ompounds on the Agenda and Further Information Required General consideration items List of compounds which have been evaluated by JECFA but for which an ADI and/or MRL was not recommended

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    Residue evaluation of certain veterinary drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA). 66th meeting 2006 2006
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    The monographs in this volume of the FAO JECFA Monographs on the residues of, statements on, or other parameters of the veterinary drugs on the agenda were prepared by the invited experts for the sixty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) held in Rome, Italy, 22-28 February, 2006. This was the seventeenth meeting of JECFA convened specifically to consider residues of veterinary drugs in food animals. The Committee has evaluated residues of veterinary drug s in food animals at the 12th, 26th, 27th, 32nd, 34th, 36th, 38th, 40th, 42nd, 43rd, 45th, 47th, 48th, 50th, 52nd, 54th, 58th, 60th, and 62nd meetings (Ref. 1-15 and 19-22, respectively). The tasks for the Committee were to further elaborate principles for evaluating the safety of residues of veterinary drugs in food and for establishing acceptable daily intakes (ADIs) and recommend maximum residue limits (MRLs) for substances on the agenda when they are administered to food producing animals in accordance with good veterinary practice in the use of veterinary drugs. The enclosed monographs provided the scientific basis for the recommendations of MRLs. There are two significant items in this volume of the FAO JECFA Monographs to bring to the attention of readers. First, this volume is the first in a new format for the presentation of monographs from meetings of the Committee. Second, this was the first meeting of JECFA subsequent to the completion of the workshop to update the principl es and methods of risk assessment for MRLs for pesticides and veterinary drugs, held jointly by FAO/RIVM/WHO, in Bilthoven, The Netherlands, 7 - 11 November, 2005. Specifically, the Committee decided to implement one of the more significant recommendations in the workshop report – the concept of using median residue values to estimate daily intakes of residues of veterinary drugs in food for chronic exposure intake estimates (Ref. 24).
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    Residue Evaluation of Certain Veterinary Drugs - Joint FAO/WHO Expert Committee on Food Additives (JECFA). Meeting 2010 – Evaluation of Data on Ractopamine Residues in Pig Tissues. FAO JECFA Monographs 9 2010
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    This meeting of JECFA, constituted in electronic format from January to May 2010, reviewed data from residue depletion studies of ractopamine hydrochloride in pig tissues, including data from three breeds of pigs in studies undertaken by the People’s Republic of China. The Committee concluded that the MRLs previously recommended are compliant with the ADI as regards consumption of pig tissues of muscle, liver, kidney and fat. Substituting specific organ tissue data for liver and kidney would res ult in dietary intakes that are still below the upper bound of the ADI, with the exception of lung tissue. However, dietary information on consumption off offal and other organ tissue such as lung are lacking and further work should be undertaken to address this issue.
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    Residue Evaluation of Certain Veterinary Drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA). 70th meeting, 2008. FAO JECFA Monographs 6 2009
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    This document contains monographs on residue evaluations of certain veterinary drugs, prepared at the seventieh meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which was held in Geneva, Switzerland from 21 to 29 October 2008. Three substances were evaluated for the first time for the animal species concerned, avilamycin, monensin and narasin. Four substances were reassessed, dexamethasone, tilmicosin, triclabendazole and tylosin. The residue monographs provide informatio n on chemical identity and properties of the compounds, pharmacokinetics and metabolism, residue depletion studies and analytical methods validated and used for the detection and quantification of the compounds. In addition to these monographs, this document includes the considerations and recommendations developed by the Committee for residues of veterinary drugs in honey and possible approaches to derive MRLs for this commodity; and a monograph on residues in aquatic species of and an estimata tion of human dietary exposure to malachite green (an antimicrobial agent and contamimant). This publication and other documents produced by JECFA contain information that is useful to those who work with or are involved with recommending or controlling maximum residue limits for veterinary drugs in foods.

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    Residue evaluation of certain veterinary drugs
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    This volume of FAO JECFA Monographs contains residue evaluation of certain veterinary drugs prepared at the 88th Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), held in Rome, 22–31 October 2019. The present meeting was the eighty-eigth in a series of similar meetings. JECFA meeting specifically convened to consider residues of veterinary drugs in food. The tasks before the Committee were to further elaborate principles for evaluating the safety of residues of veterinary drugs in food, establishing acceptable daily intakes (ADIs) and acute reference doses (ARfDs), and recommending maximum residue limits (MRLs) for such residues when the drugs under consideration are administered to food-producing animals in accordance with good practice in the use of veterinary drugs (GVP); to evaluate the safety of residues of certain veterinary drugs; and to respond to specific requests from the Codex Committee on Residues of Veterinary Drugs in Foods (CCRVDF).