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No Thumbnail AvailableBook (stand-alone)Proceedings of the first Internet Conference on Salivarian Trypanosomes. 1997
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Book (series)Drug management and parasite resistance in bovine trypanosomiasis in Africa 1998
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No results found.Trypanocidal drugs remain the principal method of animal trypanosomiasis control in most African countries. However, there is growing concern that their future effectiveness may be severely curtailed by widespread drug resistance. This document presents an overview of the current situation of resistance to drugs for the chemotherapy of trypanosomiasis in African livestock. Although the number of case reports on drug resistance is increasing, there is a lack of reliable data at the regional or national level on the true prevalence and impact of drug resistance.In order to compare data on a temporal and spatial basis across Africa there is an urgent need for better standardization of tests for the detection of drug resistance. The advantages and disadvantages of the currently available assays are briefly reviewed and measures suggested to improve the situation.Finally, some guidelines on delaying the development of drug resistance are proposed and measures which may be adopted to control drug resistance when it occurs are recommended. Although there is still a lack of knowledge about the mechanisms of resistance and the factors responsible for the development of drug resistance, urgent measures are needed to maintain the efficacy of the existing drugs. Based on experiences of the control of resistance to other drugs such as antimalarials, antibiotics and anthelmintics it is suggested that reliance on the "sanative pair" guideline might not be sufficient to control resistance to trypanocides. This guideline needs to be accompanied by the following additional measures: -
Book (stand-alone)Vector control and the elimination of gambiense human African trypanosomiasis (HAT) - Joint FAO/WHO Virtual Expert Meeting, 5-6 October 2021
PAAT Meeting Report Series, No. 1
2022Also available in:
Human African trypanosomiasis (HAT) is a vector-borne parasitic disease transmitted by tsetse flies in sub-Saharan Africa. The gambiense form of the disease (gHAT) is endemic in western and central Africa and is responsible for more than 95 percent of the HAT cases reported annually. In the road map for neglected tropical diseases 2021–2030, WHO targeted gHAT for elimination of transmission by 2030. FAO supports this goal within the framework of the Programme against African Trypanosomosis (PAAT). In the framework of the WHO network for HAT elimination, FAO and WHO convened a virtual expert meeting to review vector control in the context of gHAT elimination. The experts included health officials from endemic countries and representatives from research and academic institutions, international organizations and the private sector. Seven endemic countries provided reports on recent and ongoing vector control interventions against gHAT at national level (i.e. Angola, Cameroon, Côte d’Ivoire, Chad, Democratic Republic of the Congo, Guinea and Uganda). The country reports were followed by thematic sessions on various aspects of vector control: tools, costs, community-based approaches, monitoring and reporting. Tsetse control was also discussed in the broader framework of One Health, and in particular in relation to the control of animal trypanosomosis. This report presents a summary of the findings and lessons learned.
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