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Toxicological evaluation of certain veterinary drug residues in food: prepared by the ninety-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA)









Toxicological evaluation of certain veterinary drug residues in food: prepared by the ninety-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Geneva: World Health Organization and Food and Agriculture Organization of the United Nations; 2023 (WHO Food Additives Series, No. 85). Licence: CC BY-NC-SA 3.0 IGO


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    Book (stand-alone)
    Evaluation of certain veterinary drug residues in food: ninety-fourth report of the Joint FAO/WHO Expert Committee on Food Additives
    WHO Technical Report Series, no. 1041
    2022
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    This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of residues of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). It covers topics such as the parallel review process; estimation of dietary exposure to veterinary drug residues; a risk-based decision tree approach for safety evaluation; assessment of the potential effects of residues on the human intestinal microbiome. Summaries follow the Committee’s evaluations of toxicological and residue data on a variety of veterinary drugs: two antiparasitic agents (imidacloprid, ivermectin) and one coccidiostat (nicarbazin). Additionally, further evaluation of the parasiticide selamectin is included as part of a pilot in support of the proposed parallel review process. Annexed to the report is a summary of the Committee’s recommendations on these drugs, including acceptable daily intakes and proposed maximum residue limits.
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    Book (stand-alone)
    Evaluation of certain veterinary drug residues in food
    Eighty-eighth report of the Joint FAO/WHO Expert Committee on Food Additives
    2020
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    This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of residues of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), including harmonization of residue definition, use of scientific literature in risk assessment, toxicological profiling of compounds and less-than-lifetime dietary exposure assessment, combined exposure to multiple chemicals, and microbiological effects on the safety evaluation of veterinary drug residues in food. Summaries follow the Committee’s evaluations of toxicological and residue data on a variety of veterinary drugs: three insecticides (diflubenzuron, ethion and flumethrin), three antimicrobials (fosfomycin, halquinol and ivermectin) and one antiparasitic agent (selamectin). Annexed to the report is a summary of the Committee’s recommendations on these drugs, including acceptable daily intakes (ADIs) and proposed MRLs.
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    Book (series)
    Residue Evaluation of Certain Veterinary Drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA), 78th Meeting 2013. FAO JECFA Monographs 15 2014
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    This document contains monographs on residue evaluations of certain veterinary drugs, prepared at the seventy-eight meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which was held in Geneva, Switzerland, from 5 to 14 November 2013. Four substances were evaluated for the first time – emamectin benzoate, gentian violet, lasalocid sodium and zilpaterol hydrochloride. Four additional substances were re-evaluated – derquantel, ivermectin, monepantel and recombinant bovine soma totrophins. The monographs provide information on chemical identity and properties of the compounds, pharmacokinetics and metabolism, residue depletion studies and analytical methods validated and used for the detection and quantification of the compounds. In addition, this document provides an overview of the pilot project to evaluate alternative approaches to estimate daily intakes of residues of veterinary drugs in foods and provides guidance on the extrapolation of MRLs to minor species and for the establishment of MRLs in honey. This publication and other documents produced by JECFA contain information that is useful to all those who work with or are involved with recommending or controlling maximum residue limits for veterinary drugs in foods of animal origin.

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