Related items
Showing items related by metadata.
-
Brochure, flyer, fact-sheetInvestigating potential recombination of MERS-CoV and SARS-CoV-2 or other coronaviruses in camels
Supplementary recommendations for the epidemiological investigation of SARS-CoV-2 in exposed animals
2021Also available in:
No results found.Dromedary camels are the main reservoir for Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Genetic analysis of MERS-CoV isolates from humans and dromedaries revealed that direction of transmission is from camels to humans. Furthermore, several studies reported evidence of camel infection by other human CoVs, animal CoVs or unknown coronaviruses. There is evidence of recombination between different betacoronaviruses in camels. Analysis of the Angiotensin converting enzyme 2 receptor (ACE2) binding in dromedaries predicted potential binding affinity to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) receptor binding domain (RBD), however some other studies predicted the contrary. With the pandemic spread of SARS-CoV-2, it is not a matter of if but rather when camels will be exposed to SARS-CoV-2 in these countries. Co-circulation of both viruses in the same host can favour virus recombination, and may lead to increased virulence in animals and/or humans if the recombinant virus incorporates pathogenicity of MERS-CoV with the transmissibility of SARS-CoV-2. Further investigations into camel susceptibility to SARS-CoV-2, the possibility for recombination between MERS-CoV and SARS-CoV-2 or other coronaviruses in camels, and the associated zoonotic potential are therefore urgently required to ensure early-detection of such events. -
Book (series)Swab and tissue sample collection procedures enhancing MERS-CoV detection in camels
An illustrative guideline
2019Also available in:
No results found.Dromedary camels are thought to be the natural reservoir of MERS-CoV and can be a source of infection for humans. This document provides simplified guidelines on good practices to reach the turbinate respiratory epithelium in live and slaughtered camels with the aim of collecting high quality samples in order to enhance MERS-CoV detection, isolation and characterization; in addition, common errors and biosecurity flaws that affects the RT-PCR results are described. The manuscript will be the first document to provide practical illustrated guidance on how to collect high quality samples from the nasal turbinate of camels for the purpose of MERS-CoV detection. -
Book (series)Human Exposure to Middle East Respiratory Syndrome Coronavirus from Livestock or Wildlife Species 2017
Also available in:
No results found.Recurrent outbreaks of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in humans have been reported, mainly from the Arabian Peninsula, since 2012, with a notable outbreak in Republic of Korea from May through July 2015. To evaluate the role of domestic and wild animals, in particular dromedary camels and bats, and assess the likelihood of human exposure to MERS-CoV (i) through direct contact with these animals, (ii) while handling and consuming their products (milk, meat, urine) and (iii) from the environment at the animal-human interface (e.g. farms, households, slaughterhouses, markets, etc.), FAO prepared this qualitative release assessment. This assessment is based on information available as of 19 May 2017 and will be revised as circumstances change. It focuses on livestock-related aspects and is therefore restricted to an exposure assessment at the animal-human interface (i.e. a description of biological pathways necessary for exposure of humans to MERS-CoV released from animals and the estimation of its probability). For further aspects of the human infection and detailed consequence assessments, please refer to risk assessments by the World Health Organization (WHO).
Users also downloaded
Showing related downloaded files
No results found.