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Questions and Answers on Enterobacter sakazakii in powdered infant formula







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    Enterobacter sakazakii and other microorganisms in powdered infant formula - Meeting report. Microbiological Risk Assessment Series (MRA) 6 2004
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    Microorganisms, and in particular Enterobacter sakazakii, in powdered infant formula are considered to be an emerging public health issue. This issue was recently brought to the attention of the Codex Alimentarius, which has decided to revise its Recommended International Code of Hygienic Practices for Foods for Infants and Children in order to address concerns raised by pathogens that may be present in infant formula. FAO and WHO convened an expert meeting with the objective of providing scien tific advice to facilitate this revision process. This volume reports on the findings of that meeting. E. sakazakii has caused disease in all age groups. Statistics indicate that infants, in particular pre-term, underweight or immunocompromised infants, are at greatest risk. Powdered infant formula is not a sterile product and may occasionally contain pathogens even when it meets the current Codex standards. This report looks at range of control strategies during both manufacture and subsequen t use of powdered infant formula that may be implemented to minimize the risk. This volume and others in this Microbiological Risk Assessment Series contain information that is useful to both risk assessors and risk managers, the Codex Alimentarius Commission, governments and food regulatory agencies, industries, care givers to infants and other people or institutions with an interest in the area of microorganisms in powdered infant formula, their impact on public health and food trade, and p otential control strategies.
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    Enterobacter sakazakii and Salmonella in Powdered Infant Formula: Meeting Report. Microbiological Risk Assessment Series (MRA) 10 2006
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    The 37th Session of the Codex Committee on Food Hygiene (2005) requested the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO) to extend the scientific advice provided by the expert meeting on “Enterobacter sakazakii and other microorganisms in powdered infant formula” held in Geneva in 2004 (FAO/WHO, 2004). Accordingly, a technical meeting was convened on E. sakazakii and Salmonella in powdered infant formula (FAO, Rome, 16-20 January 2006) to consider any new scientific data and to evaluate and apply a quantitative risk assessment model for E. sakazakii in powdered infant formula (PIF). This technical meeting also aimed to provide input to Codex for the revision of the Recommended International Code of Hygienic Practice for Foods for Infants and Children.
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    Enterobacter sakazakii (Cronobacter spp.) in powdered follow-up formula: Meeting Report. Microbiological Risk Assessment Series (MRA) 15 2008
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    E. sakazakii (Cronobacter spp.) is a Gram-negative, motile, peritrichous non-spore forming, facultative anaerobic bacterium. It is an opportunistic pathogen and has been linked with serious infections in infants (FAO/WHO, 2004, 2006; Mullane et al., 2007a), notably following the consumption of PIF. Often described as an emerging pathogen, E. sakazakii (Cronobacter spp.) can cause bacteraemia and meningitis in infants and has also been isolated from infants in association with necrotizi ng enterocolitis (NEC). The first cases attributed to this organism occurred in 1958 in England (Urmenyi and Franklin, 1961). Since then and up to July 2008, the meeting has identified around 120 documented cases of E. sakazakii infection and at least 27 deaths from all parts of the world, in the published literature and in reports submitted by public health organizations and laboratories (Annex 1).

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