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Residue Evaluation of Certain Veterinary Drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA), 81st Meeting, 2015. FAO JECFA Monograph 18













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    Residue Evaluation of Certain Veterinary Drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA). 70th meeting, 2008. FAO JECFA Monographs 6 2009
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    This document contains monographs on residue evaluations of certain veterinary drugs, prepared at the seventieh meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which was held in Geneva, Switzerland from 21 to 29 October 2008. Three substances were evaluated for the first time for the animal species concerned, avilamycin, monensin and narasin. Four substances were reassessed, dexamethasone, tilmicosin, triclabendazole and tylosin. The residue monographs provide informatio n on chemical identity and properties of the compounds, pharmacokinetics and metabolism, residue depletion studies and analytical methods validated and used for the detection and quantification of the compounds. In addition to these monographs, this document includes the considerations and recommendations developed by the Committee for residues of veterinary drugs in honey and possible approaches to derive MRLs for this commodity; and a monograph on residues in aquatic species of and an estimata tion of human dietary exposure to malachite green (an antimicrobial agent and contamimant). This publication and other documents produced by JECFA contain information that is useful to those who work with or are involved with recommending or controlling maximum residue limits for veterinary drugs in foods.
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    Residue Evaluation of Certain Veterinary Drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA), 78th Meeting 2013. FAO JECFA Monographs 15 2014
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    This document contains monographs on residue evaluations of certain veterinary drugs, prepared at the seventy-eight meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which was held in Geneva, Switzerland, from 5 to 14 November 2013. Four substances were evaluated for the first time – emamectin benzoate, gentian violet, lasalocid sodium and zilpaterol hydrochloride. Four additional substances were re-evaluated – derquantel, ivermectin, monepantel and recombinant bovine soma totrophins. The monographs provide information on chemical identity and properties of the compounds, pharmacokinetics and metabolism, residue depletion studies and analytical methods validated and used for the detection and quantification of the compounds. In addition, this document provides an overview of the pilot project to evaluate alternative approaches to estimate daily intakes of residues of veterinary drugs in foods and provides guidance on the extrapolation of MRLs to minor species and for the establishment of MRLs in honey. This publication and other documents produced by JECFA contain information that is useful to all those who work with or are involved with recommending or controlling maximum residue limits for veterinary drugs in foods of animal origin.
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    Ivermectin. Residue Monograph prepared by the meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), 81st meeting 2015
    JECFA Monographs 18
    2016
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    Ivermectin (CAS No. 70288-86-7)2 is a macrocyclic lactone that is a member of the avermectin series and is widely used as a broad-spectrum antiparasitic endectocide against nematode and arthropod parasites in food-producing animals. In human medicine, ivermectin is used to treat onchocerciasis, lymphatic filariasis, strongiloidiasis and scabies. Ivermectin consists of two homologous compounds, 22,23-dihydroavermectin B1a (H2B1a or ivermectin B1a) and 22,23-dihydroavermectin B1b (H2B1b or ivermec tin B1b), in the H2B1a:H2B1b ratio of 80:20. Ivermectin is used in cattle, sheep, goats, pigs, horses, reindeer and American bison at doses of 0.1–0.5 mg/kg bw given subcutaneously, topically or orally, as a single dose treatment only. Withdrawal periods range from 14 to 122 days where ivermectin is approved for use.

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    Residue Monograph prepared by the meeting of the Joint FAO/WHO Expert Committee on Food Additives. (JECFA), 86th meeting, 12-21 June 2018
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    Benzoic acid and its salts - Chemical and Technical Assessment (CTA). 92nd JECFA 2022
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    This Chemical and Technical Assessment (CTA) summarizes the information on benzoic acid (INS No. 210) and its salts such as sodium benzoate (INS No. 211), potassium benzoate (INS No. 212) and calcium benzoate (INS No. 213) that are synthetic antimicrobial preservatives.
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    The future of food and agriculture - Trends and challenges 2017
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    What will be needed to realize the vision of a world free from hunger and malnutrition? After shedding light on the nature of the challenges that agriculture and food systems are facing now and throughout the 21st century, the study provides insights into what is at stake and what needs to be done. “Business as usual” is not an option. Major transformations in agricultural systems, rural economies, and natural resources management are necessary. The present study was undertaken for the quadrennial review of FAO’s strategic framework and for the preparation of the Organization Medium-Term plan 2018-2021.