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Residue Evaluation of Certain Veterinary Drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA), 81st Meeting, 2015. FAO JECFA Monograph 18

Year of publication 2016

Place of publication Rome, Italy ;

Pages 228 p.

Author FAO

Publisher FAO ;

Product type Book (series)

ISBN 978-92-5-109210-1

Series title Joint FAO/WHO Expert Committee on Food Additives (JECFA) Monographs

Series number 18

Synopsis (short abstract) This volume of FAO JECFA Monographs contains residue evaluation of certain veterinary drugs prepared at the 81st Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), held in Rome, Italy, 17–26 November 2015. This JECFA meeting was convened specifically to consider residues of veterinary drugs in food-producing animal species, to further elaborate principles for evaluating the safety of residues of veterinary drugs in food and for establishing acceptable daily intakes (ADIs) a nd/or acute reference doses (ARfDs), and to recommend maximum residue limits (MRLs) for substances on the agenda when they are administered to food-producing animals in accordance with good veterinary practice in the use of veterinary drugs. The monographs contained therein provide the scientific basis for the recommendations of MRLs.

Language English

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    Ivermectin (CAS No. 70288-86-7)2 is a macrocyclic lactone that is a member of the avermectin series and is widely used as a broad-spectrum antiparasitic endectocide against nematode and arthropod parasites in food-producing animals. In human medicine, ivermectin is used to treat onchocerciasis, lymphatic filariasis, strongiloidiasis and scabies. Ivermectin consists of two homologous compounds, 22,23-dihydroavermectin B1a (H2B1a or ivermectin B1a) and 22,23-dihydroavermectin B1b (H2B1b or ivermec tin B1b), in the H2B1a:H2B1b ratio of 80:20. Ivermectin is used in cattle, sheep, goats, pigs, horses, reindeer and American bison at doses of 0.1–0.5 mg/kg bw given subcutaneously, topically or orally, as a single dose treatment only. Withdrawal periods range from 14 to 122 days where ivermectin is approved for use.
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