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Regional workshop on MERS-CoV and One Health: Doha Declaration

Doha, Qatar, 27-29 April 2015








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    Global technical meeting on MERS-CoV and other emerging zoonotic coronaviruses
    Virtual meeting, 15–16 November 2021
    2022
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    Over the last nine years, FAO, WHO and WOAH have worked with Member States, public health professionals and experts across multiple sectors and technical disciplines to improve preparedness and response capacities for MERS-CoV and other high threat zoonotic pathogens around the world. This work continues to bring together public health and animal health experts from affected and at-risk countries, scientists, and subject matter experts of high threat respiratory pathogens to review the latest scientific evidence on MERS-CoV and improve multi-sectoral collaboration. As a follow-up to previous technical meetings on MERS-CoV hosted by FAO, WHO and WOAH, a Global Technical Meeting was convened virtually on 15-16 November 2021 to share the latest findings from accelerated efforts to implement the MERS-CoV public health research agenda and research and development (R&D) road map, in the context of the ongoing COVID-19 pandemic. This documents presents a summary of the presentations and discussions.
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    Brochure, flyer, fact-sheet
    Investigating potential recombination of MERS-CoV and SARS-CoV-2 or other coronaviruses in camels
    Supplementary recommendations for the epidemiological investigation of SARS-CoV-2 in exposed animals
    2021
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    Dromedary camels are the main reservoir for Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Genetic analysis of MERS-CoV isolates from humans and dromedaries revealed that direction of transmission is from camels to humans. Furthermore, several studies reported evidence of camel infection by other human CoVs, animal CoVs or unknown coronaviruses. There is evidence of recombination between different betacoronaviruses in camels. Analysis of the Angiotensin converting enzyme 2 receptor (ACE2) binding in dromedaries predicted potential binding affinity to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) receptor binding domain (RBD), however some other studies predicted the contrary. With the pandemic spread of SARS-CoV-2, it is not a matter of if but rather when camels will be exposed to SARS-CoV-2 in these countries. Co-circulation of both viruses in the same host can favour virus recombination, and may lead to increased virulence in animals and/or humans if the recombinant virus incorporates pathogenicity of MERS-CoV with the transmissibility of SARS-CoV-2. Further investigations into camel susceptibility to SARS-CoV-2, the possibility for recombination between MERS-CoV and SARS-CoV-2 or other coronaviruses in camels, and the associated zoonotic potential are therefore urgently required to ensure early-detection of such events.
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    Book (series)
    Human Exposure to Middle East Respiratory Syndrome Coronavirus from Livestock or Wildlife Species 2017
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    Recurrent outbreaks of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in humans have been reported, mainly from the Arabian Peninsula, since 2012, with a notable outbreak in Republic of Korea from May through July 2015. To evaluate the role of domestic and wild animals, in particular dromedary camels and bats, and assess the likelihood of human exposure to MERS-CoV (i) through direct contact with these animals, (ii) while handling and consuming their products (milk, meat, urine) and (iii) from the environment at the animal-human interface (e.g. farms, households, slaughterhouses, markets, etc.), FAO prepared this qualitative release assessment. This assessment is based on information available as of 19 May 2017 and will be revised as circumstances change. It focuses on livestock-related aspects and is therefore restricted to an exposure assessment at the animal-human interface (i.e. a description of biological pathways necessary for exposure of humans to MERS-CoV released from animals and the estimation of its probability). For further aspects of the human infection and detailed consequence assessments, please refer to risk assessments by the World Health Organization (WHO).

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