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The impact of veterinary drug residues on the gut microbiome and human health

A food safety perspective












FAO. 2023. The impact of veterinary drug residues on the gut microbiome and human health – A food safety perspective. Food Safety and Quality Series, No. 20. Rome.




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    The impact of pesticide residues on the gut microbiome and human health
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    With a food safety focus, a scientific literature review was conducted to characterize the current understanding about the effects of pesticide residues on the human gut microbiome and potential implications on human health and non-communicable diseases (NCDs). The main aspects analysed are (1) effects of individual or combined pesticides on the composition, diversity and function of gut microbiome using in vivo or in vitro models; (2) health implications resulting from the pesticide-microbiome interactions and underlying mechanisms; (3) establishment of causality; and (4) influence of the gut microbiome on the metabolism and bioavailability of pesticides. The research was also scoped to identify current gaps, limitations and needs for the eventual consideration of microbiome-related data in chemical risk assessment. With this work, ESF contributes to the FAO global programme on the impact of food systems on NCDs and obesity, by understanding the potential health implications of gut microbiome-pesticide interactions. The outcomes will provide information which can be used to improve nutritional strategies and food safety policies.
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    With a food safety focus, a scientific literature review was conducted to characterize the current understanding about the effects of microplastics on the gut microbiome and potential health implications. The main aspects analysed are (1) the effects of microplastics on the composition, diversity and function of gut microbiome using in vito and in vivo models; (2) health implications resulting from the microplastic–microbiome interactions and underlying mechanisms; (3) the establishment of causality; and (4) influence of the gut microbiome on microplastic biodegradation. The research was also scoped to identify current gaps, limitations and needs for the eventual consideration of microbiome-related data in chemical risk assessment. With this work, ESF contributes to the FAO global programme on the impact of food systems on NCDs and obesity, by understanding the potential health implications of gut microbiome–microplastic interactions. The outcomes will provide information which can be used to improve food safety policies.
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    Booklet
    JECFA Toolbox for Veterinary Drug Residues Risk Assessment
    Section 0. Introduction and outline
    2024
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    The use of veterinary drugs in food-producing animals can leave residues that may pose a risk to consumers when they consume animal-derived food products. A rigorous scientific assessment can help mitigate these risks while facilitating the international trade of animal-derived food products.Consult the guidance document on the introduction to the JECFA veterinary drug residue risk assessment process to: • get an overview of the purpose and content of the toolbox; • understand how JECFA interacts with other agencies, participants and stakeholders in the broader veterinary drug residue risk analyses; and• read a Q&A on the Codex Committee on Residues of Veterinary Drugs in Food (CCRVDF) and JECFA.This publication is part of the FAO JECFA Toolbox for Veterinary Drug Residue Risk Assessment. The toolbox provides practical guidance on the principles, modalities and technical requirements of JECFA in assessing the risks of veterinary drug residues in food and in recommending MRLs.

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