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BookletJECFA Toolbox for Veterinary Drug Residues Risk Assessment
Section 0. Introduction and outline
2024The use of veterinary drugs in food-producing animals can leave residues that may pose a risk to consumers when they consume animal-derived food products. A rigorous scientific assessment can help mitigate these risks while facilitating the international trade of animal-derived food products.Consult the guidance document on the introduction to the JECFA veterinary drug residue risk assessment process to: • get an overview of the purpose and content of the toolbox; • understand how JECFA interacts with other agencies, participants and stakeholders in the broader veterinary drug residue risk analyses; and• read a Q&A on the Codex Committee on Residues of Veterinary Drugs in Food (CCRVDF) and JECFA.This publication is part of the FAO JECFA Toolbox for Veterinary Drug Residue Risk Assessment. The toolbox provides practical guidance on the principles, modalities and technical requirements of JECFA in assessing the risks of veterinary drug residues in food and in recommending MRLs. -
BookletJECFA Toolbox for Veterinary Drug Residues Risk Assessment
Section 4.2. JECFA’s approach for assessing dietary exposure to veterinary drug residues: Estimating dietary exposure using global estimated chronic dietary exposure (GECDE) and global estimated acute dietary exposure (GEADE)
2024JECFA uses a novel, data-driven process for predicting the amounts of animal-derived food products consumed by people. This process has significant impacts on the resulting drug residue exposure assessment. In this guidance document you will: • learn about the food intake processes used by JECFA and their use in the subsequent exposure estimates (global estimated chronic/acute dietary exposure; GECDE/GEADE); and• incorporate residue depletion data (average or high-level residues) from animal-derived food products with dietary food intake estimates to predict acute (GEADE) and chronic (GECDE) exposure to veterinary drug residues, using the skills learned in Section 3.This publication is part of the FAO JECFA Toolbox for Veterinary Drug Residue Risk Assessment. The toolbox provides practical guidance on the principles, modalities and technical requirements of JECFA in assessing the risks of veterinary drug residues in food and in recommending MRLs. -
BookletJECFA Toolbox for Veterinary Drug Residues Risk Assessment
Section 4.1. JECFA’s approach for assessing dietary exposure to veterinary drug residues: Estimating total residues for use in dietary exposure assessment
2024By this point, you will understand the roles of both the total residue and marker residue depletion studies. Consult the guidance document to: • review how the M:T ratios are calculated in edible tissues at any time point after drug administration; and• see how total residue estimates are calculated based on the marker residue depletion and M:T data. This publication is part of the FAO JECFA Toolbox for Veterinary Drug Residue Risk Assessment. The toolbox provides practical guidance on the principles, modalities and technical requirements of JECFA in assessing the risks of veterinary drug residues in food and in recommending MRLs.
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