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BookletTraining materialJECFA Toolbox for Veterinary Drug Residues Risk Assessment
Section 4.1. JECFA’s approach for assessing dietary exposure to veterinary drug residues: Estimating total residues for use in dietary exposure assessment
2024By this point, you will understand the roles of both the total residue and marker residue depletion studies. Consult the guidance document to: • review how the M:T ratios are calculated in edible tissues at any time point after drug administration; and• see how total residue estimates are calculated based on the marker residue depletion and M:T data. This publication is part of the FAO JECFA Toolbox for Veterinary Drug Residue Risk Assessment. The toolbox provides practical guidance on the principles, modalities and technical requirements of JECFA in assessing the risks of veterinary drug residues in food and in recommending MRLs. -
BookletTraining materialJECFA Toolbox for Veterinary Drug Residues Risk Assessment
Section 2. Hazard assessment: How health-based guidance values are derived and used in the JECFA drug residue risk assessment
2024Specific types of toxicological and microbiological data are essential for performing a robust hazard assessment of veterinary drug residues. The International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products (VICH) and other agencies provide guidance on the design and analysis of such studies. Consult the guidance document on hazard assessment to learn how JECFA identifies key study outcomes and subsequently derives relevant HBGVs, including the following processes:• Toxicological studies: Determining the no observable adverse effect level (NOAEL) from toxicological studies and selecting an appropriate uncertainty (safety) factor (UF);• Microbiological studies: How minimum inhibitory concentration (MIC) data can be used to assess relevant microbiological endpoints, such as disruption of the colonization barrier in the human colon and emergence of antimicrobial resistance; • Derivation of both chronic (acceptable daily intake) and acute (acute reference dose) health-based guidance values, and the difference between these HBGVs.This publication is part of the FAO JECFA Toolbox for Veterinary Drug Residue Risk Assessment. The toolbox provides practical guidance on the principles, modalities and technical requirements of JECFA in assessing the risks of veterinary drug residues in food and in recommending MRLs. -
BookletTraining materialJECFA Toolbox for Veterinary Drug Residues Risk Assessment
Section 3.3. Marker residue depletion studies
2024A radiolabelled study may not represent the “real-world” use of the drug. Therefore, the ensuing total residue depletion data may not accurately predict real-world residue concentrations. To determine likely “real-world” drug residues, it is necessary to conduct a separate marker residue depletion study. Consult the guidance document on marker residue depletion studies to: • understand why a marker residue depletion study is required in addition to a total residue study;• learn about the characteristics of a well-performed marker residue depletion study; • find relevant guidance documents regarding marker residue depletion study design and analytical methodology; and• access a hypothetical data set to begin practicing drug residue depletion data analysis.This publication is part of the FAO JECFA Toolbox for Veterinary Drug Residue Risk Assessment. The toolbox provides practical guidance on the principles, modalities and technical requirements of JECFA in assessing the risks of veterinary drug residues in food and in recommending MRLs.
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Book (series)Manual / guideCodex Alimentarius Commission Procedural Manual
Thirtieth edition
2025The Procedural Manual of the Codex Alimentarius Commission helps national delegations and international organizations attending as observers, participate effectively in the work of the Joint FAO/WHO Food Standards Programme. It sets out the basic rules of procedure, procedures for the elaboration of Codex standards and related texts, and basic definitions and guidelines for the operation of Codex committees. It also gives the membership of the Codex Alimentarius Commission. The 30th edition of the Codex Procedural Manual continues to work towards a harmonization of language, particularly around synonymous terminology, thus setting precedent for Codex’s other written materials. Specifically, this latest edition contains three changes to "Section 4.6: Risk analysis principles applied by the Codex Committee on Residues of Veterinary Drugs in Foods", 1) a revision of "Annex C: Approach for the extrapolation of maximum residue limits for veterinary drugs to one or more species"; 2) the inclusion of "Annex D: Criteria and procedures for the establishment of action levels for residues of veterinary drugs in food of animal origin resulting from unavoidable and unintentional veterinary drug carryover in non-target animal feed"; and 3) a consequential amendment to paragraph 133, Establishment of priority list. In "Section 5.1: Table of committees, document references and terms of reference", following the decision by the Commission to reactivate the Codex Committee on Cereals, Pulses and Legumes, this committee was moved from “commodity committees (adjourned sine die)” to “commodity committees (active)”. Finally, editorial changes have been made to more consistently apply abbreviations and provide more accurate cross-referencing by numbering subsections. -
Book (stand-alone)Technical reportPesticide residues in food 2023 – Evaluation Part 1 – Residues
Joint FAO/WHO Meeting on Pesticide Residues
2024Also available in:
No results found.The Joint FAO/WHO Meeting on Pesticide Residues (JMPR) comprises the FAO Panel on Pesticide Residues and the WHO Core Assessment Group. The WHO Core Assessment Group is responsible for reviewing pesticide toxicological data and estimating acceptable daily intake (ADI) and acute reference doses (ARfDs) and characterizing other toxicological criteria. The FAO Panel on Pesticide Residues reviews the results of a range of studies including residue field trials and processing studies. These studies, called evaluations, are conducted for each individual pesticide and published in this report for the benefit of national governments who may use the information while undertaking national assessments. -
Book (series)Manual / guideCodex Alimentarius Commission Procedural Manual
Twenty-eighth edition
2023The Procedural Manual of the Codex Alimentarius Commission helps national delegations and international organizations attending as observers, participate effectively in the work of the Joint FAO/WHO Food Standards Programme. It sets out the basic Rules of Procedure, procedures for the elaboration of Codex standards and related texts, and basic definitions and guidelines for the operation of Codex committees. It also gives the membership of the Codex Alimentarius Commission. This newly designed 28th edition with the first change in layout since the 1960s, amends the section on commodity standards dealing with non-retail containers; introduces new text on “Criteria and procedural guidelines for Codex committees and ad hoc intergovernmental task forces working by correspondence”, and there is a new annex concerning the "Approach for the extrapolation of maximum residue limits of veterinary drugs to one or more species to the risk analysis principles applied by the Committee on residues of veterinary drugs in foods".